New synthesis of 9-alkylguanines and their N<sup>2</sup>-substituted derivatives

Authors

  • П. М. Кочергин Zaporozhe State Medical Institute. Zaporozhe 330074
  • Л. B. Персанова State Institute for Blood Substitutes and Medicinal Preparations, Moscow 109044
  • E. B. Александрова Center for Drug Chemistry, All-Russian Scientific Research Institute for Pharmaceutical Chemistry, Moscow 119815

Abstract

A new method of synthesizing 9-alkyl guanines and their N2-substituted derivatives from 7-benzylguanine and its N2-substituted derivatives has been developed by quaternization with alkyl halides, dialkyl sulfates, or arenesulfonic acid esters, and subsequent removal of the benzyl protection by hydrogenation of the intermediate quaternary salts or of the betaines obtained from them.

How to Cite
Kochergin, P. M.; Persanova, L. V.; Aleksandrova, E. V. Chem. Heterocycl. Compd. 1998, 34, 480. [Khim. Geterotsikl. Soedin. 1998, 34, 542.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290890

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Published

1998-04-25

Issue

No. 4 (1998)

Section

Original Papers