THREE-COMPONENT ONE-POT SYNTHESIS OF THIAZOLO[5,4-<i>e</i>]INDOLE DERIVATIVES

Authors

  • Bing-Wei Wang Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, 222000
  • Kai-Qi Pu Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, 222000
  • Xue Wang Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, 222000
  • Dong-Sheng Chen Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, 222000 https://orcid.org/0000-0002-1738-1896

Keywords:

arylglyoxals, 1,3-benzothiazol-6-amine, cyclohexane-1,3-dione, thiazolo[5,4-e]indole, three-component reaction

Abstract

A practical and environmentally benign protocol for the synthesis of polysubstituted thiazolo[5,4-e]indoles has been developed. This method employs arylglyoxals, 1,3-benzothiazol-6-amine, and 5,5-dimethylcyclohexane-1,3-dione or cyclohexane-1,3-dione as starting materials. The synthetic approach is metal-free, the reaction conditions are mild, and the product is readily separable.

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Published

2025-09-18

Issue

Vol. 61 No. 5/6 (2025)

Section

Original Papers