Synthesis and properties of 3-amino-2-(2-benzimidazolyl)-Δ²-pyrrolizidin-1-one

Abstract

2-Benzimidazolylacetonitrile is acetylated by the acid chloride derivative of N-trifluoroacetylproline to give N- and C-acyl derivatives. Removal of the trifluoroacetyl protective group in the C-acyl derivatives is accompanied by cyclization to give 3-amino-2-(2-benzimidazolyl)-Δ²-pyrrolizidin-1-one. Exhaustive acylation of this product gives a derivative of a new heterocyclic system, namely, pyrrolizino[3',2':5,6]-pyrimido[3,4-a]benzimidazole.

How to Cite
Volovenko, Y. M. Chem. Heterocycl. Compd. 1997, 33, 854. [Khim. Geterotsikl. Soedin. 1997, 975.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02253040