Reaction of 2-alkoxy-2-methylthio-5,6-dihydro-4H-1,3-thiazines with phenoxyacetyl chloride

Abstract

The reaction of 4-alkoxytetrahydro-1,3-thiazine-2-thiones with methyl iodide and subsequent treatment of the resultant S-alkylation products by suitable sodium alcoholates yielded 4-alkoxy-2-methylthio-5,6-dihydro-4H-1,3-thiazines, which upon reaction with phenoxyacetyl chloride in the presence of triethylamine was stereospecifically converted into 4-alkoxy-6-methylthio-7-phenoxycephams.

How to Cite
Shutalev, A. D.; Pagaev, M. T. Chem. Heterocycl. Compd. 1996, 32, 487. [Khim. Geterotsikl. Soedin. 1996, 557.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01165919