Synthesis of 2,7-naphthyridines by the recyclization of trimethylformylpiperidone

Authors

  • B. А. Артемов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • А. М. Шестопалов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • В. П. Литвинов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow

Abstract

The structure of the product of interaction of the sodium salt of 1,2,5-trimethyl-3-formylpiperid-4-one with cyanothioacetamide was specified. It was shown that the Knoevenagel adduct formed at the first stage in basic conditions undergoes recyclization with the formation of 1,2,3,5,6,7,8,8a-octahydro-1-oxo-6,7,8a-trimethyl-4-cyano-2,7-naphthyridine-3-thione, the structure of which was confirmed by the data of physicochemical methods of analysis and chemical conversions.

How to Cite
Artemov, V. A.; Shestopalov, A. M.; Litvinov, V. P. Chem. Heterocycl. Compd. 1996, 32, 445. [Khim. Geterotsikl. Soedin. 1996, 512.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01165908

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Published

1996-04-25

Issue

No. 4 (1996)

Section

Original Papers