ANODIC CYCLIZATION: A PROTOCOL FOR THE GREEN SYNTHESIS OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES

Authors

  • S. Singh University of Allahabad
  • L. K. Sharma University of Allahabad
  • A. Saraswat University of Allahabad
  • M. K. Srivastava University of Allahabad
  • I. R. Siddiqui University of Allahabad
  • R. K. P. Singh University of Allahabad

DOI:

https://doi.org/10.1007/1089

Keywords:

1, 3, 4-oxadiazoles, Pt anode, controlled potential electrolysis, cyclic voltammetry, electrochemical oxidation, electron transfer, green chemistry

Abstract

An efficient and simple one-pot synthesis of chemically and pharmaceutically interesting 2,5-disubstituted 1,3,4-oxadiazoles is reported. The protocol involves anodic oxidation of N'-aroylhydrazones of aromatic aldehydes using LiClO4 as supporting electrolyte in MeCN solution under controlled potential at room temperature. The products were characterized by spectroscopic methods, and mechanism was deduced from voltammetry studies. The mild reaction conditions, short reaction time, and excellent yields are notable advantages of the developed protocol.

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Published

2013-10-30

Issue

No. 10 (2013)

Section

Original Papers