DEVELOPMENT OF AN ALANINE-DERIVED CHIRAL STABILIZED AZOMETHINE YLID BASED ON THE 5-(2'-NAPHТHYL)MORPHOLIN-2-ОNE TEMPLATE

Authors

  • Amberley S. Anslow Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY
  • Geoffrey G. Cox Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY
  • Laurence M. Harwood Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY

Abstract

A route to enantiomerically pure α-methyl functionalized proline derivatives is presented, using a 1,3-dipolar cycloaddition strategy based upon a homochiral 5-(2′-naphthyl)morpholin-2-one template. A mild means of generating stabilized azomethine ylids using sonication and Lewis acid catalysis is developed, avoiding the use of excessive temperatures.

How to Cite
Anslow, A. S.; Cox, G. G.; Harwood, L. M. Chem. Heterocycl. Compd. 1995, 31, 1222. [Khim. Geterotsikl. Soedin. 1995, 1393.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01185597

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Published

1995-10-25

Issue

No. 10 (1995)

Section

Original Papers