5',6',7',8'-TETRAHYDRO-1'<i>H</i>,3'<i>H</i>-SPIRO[CYCLOHEXANE-1,2'-QUINAZOLIN]-4'-ONE IN MANNICH REACTION

Abstract

The Mannich aminomethylation of 5',6',7,'8'-tetrahydro-1'H,3'H-spiro[cyclohexane-1,2'-quinazolin]-4'-one leads to formation of a heterocyclic system containing an annelated azabicyclic fragment. Hydrolysis of the indicated spirans gives 3-azabicyclo[3.3.1]nonanes.

Authors: V. I. Markov and O. K. Farat.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (6), pp 925-930

http://link.springer.com/article/10.1007/s10593-012-1078-z