POLAROGRAPHIC INVESTIGATION OF THE METRONIDAZOLE COMPLEX WITH POLYVINYLPYRROLIDONE

Authors

  • Т. И. Вакульская A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • Л. И. Ларина A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • В. А. Лопырев A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences

DOI:

https://doi.org/10.1007/1346

Keywords:

1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, metronidazole, polyvinylpyrrolidone, Britton-Robinson buffer media, complexes, electrochemical reduction, hydrogen bond, polarography

Abstract

Polarographic behavior of the metronidazole complex with polyvinylpyrrolidone in Britton-Robinson buffer solutions have been studied. This complex possesses prolonged antimicrobial action. Complexation with polyvinylpyrrolidone was shown to alter the mechanism of metronidazole reduction and increases its solubility in water. The temperature dependence of the limiting currents indicates the formation of additional hydrogen bonds in the complex, which restricts diffusion of the depolarizer to the cathode.

Authors: T. I. Vakul'skaya, L. I. Larina, and V. A. Lopyrev.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (11), pp 1372-1377

http://link.springer.com/article/10.1007/s10593-012-0923-4

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Published

2013-12-11

Issue

No. 11 (2011)

Section

Original Papers