SYNTHESIS AND ANTI-HEPATITIS B VIRUS ACTIVITY OF NEW PYRIMIDINE PEPTIDE NUCLEIC ACID ANALOGS

Authors

  • R. A. K. Al-Harbi Department of Applied Chemistry, Faculty of Applied Science, Taibah University
  • A. A.-H. Abdel-Rahman Department of Chemistry, Faculty of Science, Northern Border University

DOI:

https://doi.org/10.1007/1375

Keywords:

peptide nucleic acid analogs, pyrimidine nucleobases, anti-hepatitis B virus activity

Abstract

A series of 4-methylsulfanylpyrimidin-2(1H)-one peptide nucleic acid analogs were synthesized and tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine the virus count reduction as a result of treatment with tested compounds.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (10), pp 1290-1297

http://link.springer.com/article/10.1007/s10593-012-0905-6

Downloads

Published

2013-12-13

Issue

No. 10 (2011)

Section

Original Papers