SYNTHESIS OF ALKYL HEXAHYDROPYRAZINO[1,2-<i>c</i>]PYRIMIDINE-9-CARBOXYLATES

Authors

  • М. В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine
  • О. В. Кушнир Yu. Fedkovich Chernivtsi National University
  • Н. В. Мельниченко Institute of Organic Chemistry, National Academy of Sciences of Ukraine
  • И. Ф. Цымбал Institute of Organic Chemistry, National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.1007/1417

Keywords:

3-alkoxycarbonylmethylidenepiperazin-2-ones, 1-aryl-2, 2, 2-trifluoroethyl isocyanates, α-chlorobenzyl isocyanates, pyrazino[1, 2-c]pyrimidine-9-carboxylates, cyclocondensation

Abstract

Cyclocondensation of 3-alkoxycarbonylmethylidenepiperazin-2-ones with α-chlorobenzyl isocyanates gave alkyl 8-aryl-1,6-dioxo-1,3,4,6,7,8-hexahydro-2H-pyrazino[1,2-c]pyrimidine-9-carboxylates. The use of 1-aryl-2,2,2-trifluoroethyl isocyanates in an analogous cyclization gave 6-aryl-1,8-dioxo-6-trifluoromethyl-1,3,4,6,7,8-hexahydro-2H-pyrazino[1,2-c]pyrimidine-9-carboxylates.

Authors: M. V. Vovk, O. V. Kushnir, N. V. Mel'nichenko, and I. F. Tsymbal.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (8), pp 989-995

http://link.springer.com/article/10.1007/s10593-011-0865-2

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Published

2013-12-19

Issue

No. 8 (2011)

Section

Original Papers