SYNTHESIS OF 3-AMINOPYRIDINE-2(1<I>H</I>)-ones and 1<I>H</I>-pyrido[2,3-<I>b</I>][1,4]oxazin-2(3<I>H</I>)-ones
DOI:
https://doi.org/10.1007/1426Keywords:
3-aminopyridin-2(1H)-ones, enaminoketones, N-(3-oxoalkenyl)amides, chloroacetamides, intramolecular cyclizationAbstract
From the interaction of 1,3-diketones with chloroacetamide N-(3-oxoalkenyl)chloroacetamides were obtained. Heating of N-(3-oxoalkenyl)chloroacetamides with an excess of pyridine in ethanol or butanol lead to the formation of pyridin-2(1Н)-ones containing a pyridinium cycle in the position 3. From the interaction of these compounds with hydrazine hydrate 3-aminopyridin-2(1Н)-ones were obtained. The synthesis of 1H-pyrido[2,3-b][1,4]oxazin-2(3H)-ones was carried out by means of the reaction of 3-aminopyridin-2(1Н)-ones with monochloroacetic chloride.
How to Cite
Fisyuk, A. S.; Kulakov, I. V.; Goncharov, D. S.; Nikitina, O. S.; Bogza, Y. P.; Shatsauskas, A. L. Chem. Heterocycl. Compd. 2014, 50, 217. [Khim. Geterotsikl. Soedin. 2014, 241.]
For this article in the English edition see DOI 10.1007/s10593-014-1464-9
Synthesis of 3-aminopyridine-2(1H)-ones and 1H-pyrido[2,3-b][1,4]oxazin-2(3H)-ones