MODIFICATION OF THE PICTET–SPENGLER REACTION IN THE SYNTHESIS OF FUSED 2,3-BENZODIAZOCINES
DOI:
https://doi.org/10.1007/1444Keywords:
3-amino-2-[2-(3, 4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one, fused diazocines, hydrochloric acid, tetrahydroquinazolino[3, 2-c][2, 3]benzodiazocin-15-ones, trifluoroacetic acid, cyclization, Pictet–Spengler reactionAbstract
A new strategy for the synthesis of the eight-membered heterocyclic skeleton of tetrahydroquinazolino[3,2-c][2,3]benzodiazocin-15-ones, based on the Pictet–Spengler reaction of 3‑amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one with carbonyl compounds in acidic media, is proposed.
Authors: A. S. Tolkunov, V. N. Baumer, G. V. Palamarchuk, O. V. Shishkin, A. V. Mazepa, S. V. Tolkunov, and S. L. Bogza
English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (8), pp 1006-1013
