SYNTHESIS, SPECTRAL ANALYSIS, AND <i>IN VITRO</i> MICROBIOLOGICAL EVALUATION OF ETHYL 7,9-DIARYL-1,4-DIAZASPIRO[4.5]DEC-9-ENE-6-CARBOXYLATES AS A NEW CLASS OF ANTIBACTERIAL AND ANTIFUNGAL AGENTS

Authors

  • J. Thanusu Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University
  • V. Kanagarajan Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University
  • M. Gopalakrishnan Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University

DOI:

https://doi.org/10.1007/1516

Keywords:

ethyl 7, 9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates, ethylene-diamine, p-toluenesulfonic acid, antibacterial activity, antifungal activity

Abstract

A new series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6-carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex-3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (5), pp 575-583

http://link.springer.com/article/10.1007/s10593-011-0801-5

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Published

2014-01-22

Issue

No. 5 (2011)

Section

Original Papers