SUBSTITUTED QUINOLINONES. 15. PREPARATION AND ENZYMATIC ACTIVITY OF SOME PYRAZOLOAZINES LINKED TO 4-HYDROXY-1-METHYLQUINOLIN-2(1<i>H</i>)-ONE MOIETY

Abstract

Heterocyclization reaction of pyrazolinylquinolinone and its 4-chlorobenzylidene, 2-pyridylmethylene, pyridylaminomethylene, and 2-pyridylhydrazone derivatives with some active methylene nitriles and acrylonitriles, is described. These cyclization reactions afforded novel heterocyclic systems, such as pyrazolo[3,4-b]pyridines, pyrano[2,3-c]pyrazoles, and pyrazolo[4,3-c]pyridazines, linked to position 3 of 4-hyd- roxy-1-methylquinolin-2(1H)-one. The effect of the new products on the activity of α-amylase was examined. Some pyrano[2,3-c]pyrazoles revealed significant increase in α-D-glucose production by the enzyme.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (5), pp 611-621

http://link.springer.com/article/10.1007/s10593-011-0806-0