SYNTHESIS OF 2-QUINOLINECARBOXAMIDE DERIVATIVES AS POTENTIAL HDAC INHIBITORS

Abstract

Inhibition of histone deacetylase activity appears as an original and effective approach for the treatment of cancer. A series of novel quinoline-containing derivatives has been synthesized and found that some of these compounds possess nanomolar histone deacetylase inhibitory activity.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 719-727

http://link.springer.com/article/10.1007/s10593-011-0825-x