4-HYDROXY-2-QUINOLONES 196. SYNTHESIS AND BROMINATION OF 1-ALLYL-3-(2-HYDROXYETHYL)-1<i>H</i>,3<i>H</i>-QUINAZOLINE-2,4-DIONE

Abstract

The alkylation of 3-(2-hydroxyethyl)-1H,3H-quinazoline-2,4-dione and subsequent bromination of its 1-allyl derivative have been studied. The data obtained has been compared with the results of similar studies on a series of other, related compounds. A rule has been formulated which allows a prediction of 1-allyl-substituted 2-oxo azaheterocycles bromination route based upon the way in which their initial alkylation by allyl bromide in the system DMSO–K₂CO₃ occurs.

Authors: I. V. Ukrainets, E. V. Mospanova, A. V. Turov, and V. A. Parshykov

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 731-636

http://link.springer.com/article/10.1007/s10593-011-0827-8