THREE-COMPONENT SYNTHESIS OF 4-AROYL-2(1),4,5,7-TETRAHYDROPYRAZOLO[3,4-<i>b</i>]PYRIDIN-6-ONES AND THEIR PROPERTIES
Authors
O. N. Petrova
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
L. L. Zamigajlo
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
I. M. Gella
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University
V. I. Musatov
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
S. V. Shishkina
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
O. V. Shishkin
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University
E. V. Vashchenko
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine
A. V. Borisov
Enamine Ltd.
V. V. Lipson
State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University; Antidiabetic Drug Laboratory, SI "V. Ya. Danilevsky Institute for Endocrine Pathology Problems"
Inspired by the concept of multicomponent reactions, a novel one-pot synthesis involving arylglyoxals, 5-aminopyrazoles, and Meldrum's acid has been developed and employed for the creation of a small library of 4‑aroyl-2(1),4,5,7‑tetrahydropyrazolo[3,4‑b]pyridin-6-ones. The alkylation, acylation, reduction, and oxidation reactions of 4‑aroyl-3‑methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones have been studied.
