SOLVENT-FREE ONE-POT SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF NOVEL SPIROPIPERIDINYL 1,2,4-TRIAZOLIDINE-3-THIONES

Authors

  • V. Kanagarajan Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University
  • J. Thanusu Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University
  • M. R. Ezhilarasi Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University
  • M. Gopalakrishnan Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University

DOI:

https://doi.org/10.1007/2176

Keywords:

m-chloroperbenzoic acid, spiropiperidinyl 1, 2, 4-triazolidine-3-thiones, antibacterial activity, antifungal activity, one-pot synthesis

Abstract

A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, all the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.

How to Cite
Kanagarajan, V. ; Thanusu, J.; Ezhilarasi, M. R.; Gopalakrishnan, M. Chem. Heterocycl. Compd. 2011, 47(1), 60. [Khim. Geterotsikl. Soedin. 2011, 81.]

For this article in the English edition see DOI 10.1007/s10593-011-0720-5

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Published

2014-12-18

Issue

No. 1 (2011)

Section

Original Papers