AN EFFICIENT SYNTHESIS OF 1,3,7-TRIAZASPIRO[4.4]NONANE-2,4-DIONE DERIVATIVES AND ANTIMICROBIAL ACTIVITY THEREOF

Authors

  • Константин Ю. Кроленко National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine
  • Алексей В. Силин National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine
  • Сергей В. Власов National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine
  • Ирина А. Журавель National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine
  • Сергей Н. Коваленко National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine

DOI:

https://doi.org/10.1007/2314

Keywords:

hydantoin, pyrrolidine ring, alkylation, antimicrobial activity

Abstract

Efficient methods for the synthesis of 1,3,7-triazaspiro[4.4]nonane-2,4-dione derivatives possessing an unsaturated pyrrolidine cycle have been developed affording intermediates and target compounds in high yields not requiring additional purification. Antimicrobial activity of the synthesized compounds was studied.

How to Cite
Krolenko, K. Yu.; Silin, O. V.; Vlasov, S. V.; Zhuravel, I. O.; Kovalenko, S. M. Chem. Heterocycl. Compd. 2015, 51, 472. [Khim. Geterotsikl. Soedin. 2015, 51, 472.]

For this article in the English edition see DOI 10.1007/s10593-015-1721-6

 

 

Author Biographies

Константин Ю. Кроленко, National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine

Константин Юрьевич Кроленко

Аспирант кафедры токсикологической химии Национального фармацевтического университета (г. Харьков).

Алексей В. Силин, National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine

Алексей Витальевич Силин

Сергей В. Власов, National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine

Сергей Витальевич Власов

Ирина А. Журавель, National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine

Ирина Александровна Журавель

Сергей Н. Коваленко, National University of Pharmacy, 53 Pushkinskaya St., Kharkov 61002, Ukraine

Сергей Николаевич Коваленко

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Published

2015-05-28

Issue

Vol. 51 No. 5 (2015)

Section

Original Papers