SYNTHESIS AND ANTIRADICAL ACTIVITY OF 4-ARYL(HETARYL)-SUBSTITUTED 3-AMINOPYRIDIN-2(1<i>Н</i>)-ONES

Authors

  • Иван В. Кулаков Department of Organic Chemistry, F. M. Dostoevskii Omsk State University, 55a Mira Ave., Omsk 644077
  • Мария В. Мацукевич Department of Organic Chemistry, F. M. Dostoevskii Omsk State University, 55a Mira Ave., Omsk 644077
  • Зарина Т. Шульгау RSE " National Center for Biotechnology" of the Ministry of Education and Science, 13/5 Kurgalzhynskoe road, Astana 010000
  • Шынгыс Сергазы RSE " National Center for Biotechnology" of the Ministry of Education and Science, 13/5 Kurgalzhynskoe road, Astana 010000
  • Тулеген М. Сейлханов Sh. Ualikhanov Kokshetau State University, 76 Abaya St., Kokshetau 020000
  • Амрит Пузари Department of Science & Humanities, National Institute of Technology Nagaland, Pin: 797 103, Nagaland
  • Александр Семенович Фисюк Omsk State Technical University, 11 Mira Ave., Omsk 644050

DOI:

https://doi.org/10.1007/2738

Keywords:

3-aminopyridin-2(1Н)-ones, 1, 3-diketones, N-(3-oxoalkenyl)chloroacetamides, antiradical activity, intramolecular cyclization

Abstract

The reaction of aryl(hetaryl)-substituted 1,3-diketones with chloroacetamide gave the respective N-(3-oxoalkenyl)chloroacetamides, which were converted to 3-pyridinium-substituted pyridin-2(1Н)-ones upon heating with excess of pyridine in n-butanol. The decomposition of pyridinium salts with hydrazine hydrate resulted in new 4-aryl(hetaryl)-substituted 3-aminopyridin-2(1Н)-ones, which showed strong antiradical activity with respect to ABTS and DPPH radicals.

How to Cite
Kulakov, I. V.; Matsukevich, M. V.; Shulgau, Z. T.; Sergazy, Sh.; Seilkhanov, T. M.; Puzari, A.; Fisyuk, A. S. Chem. Heterocycl. Compd. 2015, 51, 991. [Khim. Geterotsikl. Soedin. 2015, 51, 991.]

For this article in the English edition see DOI 10.1007/s10593-016-1809-7

Author Biographies

Иван В. Кулаков, Department of Organic Chemistry, F. M. Dostoevskii Omsk State University, 55a Mira Ave., Omsk 644077

Ivan V. Kulakov

Мария В. Мацукевич, Department of Organic Chemistry, F. M. Dostoevskii Omsk State University, 55a Mira Ave., Omsk 644077

Mariya V. Matsukevich

Зарина Т. Шульгау, RSE " National Center for Biotechnology" of the Ministry of Education and Science, 13/5 Kurgalzhynskoe road, Astana 010000

Zarina T. Shulgau

Шынгыс Сергазы, RSE " National Center for Biotechnology" of the Ministry of Education and Science, 13/5 Kurgalzhynskoe road, Astana 010000

Shyngys Sergazy

Тулеген М. Сейлханов, Sh. Ualikhanov Kokshetau State University, 76 Abaya St., Kokshetau 020000

Tulegen M. Seilkhanov

Амрит Пузари, Department of Science & Humanities, National Institute of Technology Nagaland, Pin: 797 103, Nagaland

Amrit Puzari

Александр Семенович Фисюк, Omsk State Technical University, 11 Mira Ave., Omsk 644050

Alexander S. Fisyuk

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Published

2015-12-28

Issue

Vol. 51 No. 11/12 (2015)

Section

Original Papers