NOVEL PALLADIUM-CATALYZED DOMINO REACTION OF 2-METHYLINDOLES WITH 2-IODOBENZYL BROMIDE

Authors

  • Edgars Abele Latvian Institute of Organic synthesis
  • Sergey Belyakov Latvian Institute of Organic synthesis
  • Tatyana Beresneva Latvian Institute of Organic synthesis
  • Lena Golomba Latvian Institute of Organic synthesis
  • Ramona Abele Latvian Institute of Organic synthesis

DOI:

https://doi.org/10.1007/2768

Keywords:

2-iodobenzyl bromide, 2-methylindole, potassium t-butoxide, tricyclo[7, 3, 1, 02, 7]trideca-2(7), 5-trienes, palladium catalysis

Abstract

A novel palladium-catalyzed domino reaction of 2-methylindoles with 2-iodobenzyl bromide in the system Pd(OAc)2/Xantphos/t-BuOK/PhMe leading to indole-fused tricyclo[7,3,1,02,7]trideca-2(7),3,5-triene ring system is presented. Pd-catalyzed reaction of 2-methylindole with 5-bromo-6-bromomethylbenzo[1,3]dioxole afforded 3,3-bis(6-bromobenzo[1,3]dioxol-5-ylmethyl)-2-methyl-3H-indole.

How to Cite
Abele, E.; Belyakov, S.; Beresneva, T.; Golomba, L.; Abele, R. Chem. Heterocycl. Compd. 2016, 52, 140. [Khim. Geterotsikl. Soedin. 2016, 52, 140.]

For this article in the English edition see DOI 10.1007/s10593-016-1846-2

 

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Published

2016-03-04

Issue

Vol. 52 No. 2 (2016)

Section

Letters to the Editor