AN EFFICIENT SYNTHESIS OF (3-INDOLYL)ACETONITRILES BY REDUCTION OF HYDROXAMIC ACIDS

Authors

  • Александр B. Аксенов North-Caucasus Federal University, 1 Pushkina St., Stavropol 355009
  • Николай A. Аксенов North-Caucasus Federal University, 1 Pushkina St., Stavropol 355009
  • Зарема B. Джандигова North-Caucasus Federal University, 1 Pushkina St., Stavropol 355009
  • Инна В. Аксенова North-Caucasus Federal University, 1 Pushkina St., Stavropol 355009
  • Леонид Г. Воскресенский People’s Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow 117198
  • Александр H. Смирнов North-Caucasus Federal University, 1 Pushkina St., Stavropol 355009
  • Михаил А. Рубин University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582

DOI:

https://doi.org/10.1007/3191

Keywords:

hydroxamic acids, indoles, nitriles, reduction

Abstract

A new, highly efficient method was developed for the synthesis of (3-indolyl)acetonitriles by reduction of readily available (3-indolyl)hydroxamic acids with phosphorus trichloride. The nitriles obtained according to this method are of significant interest for structure-activity studies of potential anticancer agents.

Authors: Alexander V. Aksenov*, Nicolai A. Aksenov, Zarema V. Dzhandigova, Inna V. Aksenova, Leonid G. Voskressensky, Alexander N. Smirnov, Michael A. Rubin*

 

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Published

2016-06-03

Issue

Vol. 52 No. 5 (2016)

Section

Original Papers