SODIUM HYDROGEN SULFATE AS A CATALYST FOR THE SYNTHESIS OF <i>N</i>,4-DIARYL-6-METHYL-1-METHYL(PHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDES <i>VIA</i> THE BIGINELLI REACTION

Authors

  • Vladimir L. Gein Perm State Pharmaceutical Academy
  • Tatiana M. Zamaraeva Perm State Pharmaceutical Academy
  • Maksim V. Dmitriev Perm State University

DOI:

https://doi.org/10.1007/4138

Keywords:

aromatic aldehyde, keto amide, N-methylthiourea, N-phenylthiourea, 2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamide, Biginelli reaction.

Abstract

N,4-Diaryl-6-methyl-1-methyl(phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides were synthesized in three-component reaction of N-aryl-3-oxobutanamides, aromatic aldehyde, and N-methylthiourea (N-phenylthiourea) in ethanol in the presence of nontoxic, cheap sodium hydrogen sulfate as a catalyst. Products were obtained in moderate to high yields.

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Published

2018-03-23

Issue

Vol. 54 No. 2 (2018)

Section

Original Papers