IMPROVED METHOD FOR THE SYNTHESIS OF 1-VINYLINDOLE

Authors

  • Е. Ю. Шмидт Иркутский институт химии им. А. Е. Фаворского СО РАН
  • Н. И. Процук Иркутский институт химии им. А. Е. Фаворского СО РАН
  • А. М. Васильцов Иркутский институт химии им. А. Е. Фаворского СО РАН
  • А. В. Иванов Иркутский институт химии им. А. Е. Фаворского СО РАН
  • А. И. Михалева Иркутский институт химии им. А. Е. Фаворского СО РАН
  • Б. А. Трофимов Иркутский институт химии им. А. Е. Фаворского СО РАН

DOI:

https://doi.org/10.1007/461

Keywords:

acetylene, indole, 1-vinylindole, superbase, vinylation

Abstract

A highly efficient method has been developed for the synthesis of 1-vinylindole based on the vinylation of indole by acetylene at atmospheric pressure using the superbase KOH–DMSO catalytic system. The method allows the preparation of the 1-vinylindole in 94% yield with a purity of 99% (after a single distillation of the crude product).

Authors: E. Yu. Shmidt, N. I. Protsuk, A. M. Vasil'tsov, A. V. Ivanov, A. I. Mikhaleva, and B. A. Trofimov

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 404-407

http://link.springer.com/article/10.1007/s10593-013-1260-y

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Published

2013-04-05

Issue

No. 3 (2013)

Section

Original Papers