SYNTHESIS OF NOVEL SPIRO-CONDENSED 2-AMINO-4<i>H</i>-PYRANS BASED ON 1,2-BENZOXATHIIN-4(3<i>H</i>)-ONE 2,2-DIOXIDE

Authors

  • Galina V. Grigoriv National University of Pharmacy
  • Dmitry A. Lega National University of Pharmacy
  • Lucjusz Zaprutko Poznan University of Medical Sciences
  • Andrzej K. Gzella Poznan University of Medical Sciences
  • Ewa Wieczorek-Dziurla Poznan University of Medical Sciences
  • Valentine P. Chernykh National University of Pharmacy
  • Leonid A. Shemchuk National University of Pharmacy

DOI:

https://doi.org/10.1007/4772

Keywords:

active methylene nitrile, 1, 2-benzoxathiin-4(3H)-one 2, 2-dioxide, isatin, ninhydrin, spiro compounds, multicomponent reactions

Abstract

A series of new spiro-condensed 2-amino-4H-pyrans were synthesized by three-component interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, malononitrile, and cyclic carbonyls in moderate to high yields. This is one of the first examples of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide application in multicomponent transformations.

Author Biographies

Galina V. Grigoriv, National University of Pharmacy

Organic chemistry department

Dmitry A. Lega, National University of Pharmacy

Organic chemistry department, PhD

Lucjusz Zaprutko, Poznan University of Medical Sciences

Organic chemistry department, Dr. hab., Prof.

Andrzej K. Gzella, Poznan University of Medical Sciences

Organic chemistry department, Dr. hab., Prof.

Ewa Wieczorek-Dziurla, Poznan University of Medical Sciences

Organic chemistry department

Valentine P. Chernykh, National University of Pharmacy

Organic chemistry department, Dr. Chem. Sc., Prof., Academician of National Academy of Science of Ukraine

Leonid A. Shemchuk, National University of Pharmacy

Organic chemistry department, Prof., Dr. Chem. Sc.

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Published

2019-04-11

Issue

Vol. 55 No. 3 (2019)

Section

Original Papers