SYNTHESIS AND ANTIVIRAL EVALUATION OF 1,3-DIMETHYL-6-(1H-1,2,3-TRIAZOL-1-YL)PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES

Authors

  • A. Sh. El-Etrawy Department of Organic Chemistry, Collogue of Pharmacy, Misr University for Science and Technology, 6th October City
  • A. A.-H. Abdel-Rahman Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam

DOI:

https://doi.org/10.1007/5038

Keywords:

pyrimidine derivatives, 1, 2, 3-triazoles, anti hepatitis A virus, cycloaddition

Abstract

Some of 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the rection of a 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.

How to Cite
Chem. Heterocycl. Compd. 2010, 46, 1105. [Khim. Geterotsikl. Soedin. 2014, 1372.]

For this article in the English edition see DOI 10.1007/s10593-010-0633-8

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Published

2019-03-14

Issue

No. 9 (2010)

Section

Original Papers