SYNTHESIS OF 4-ARYL(HETARYL)PYRAZOLO[1,5-<i>a</i>]PYRAZINES BY PALLADIUM-CATALYZED SUZUKI–MIYAURA CROSS COUPLING

Authors

  • Евгений В. Гринишин National University ''Kyiv-Mohyla Academy'', 2 Hrygorija Skovorody St., Kyiv 04655, Ukraine Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Анна Р. Мусийчук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Назар М. Цизорик Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine
  • Андрей В. Больбут Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine Enamine Ltd., 67/45 Chervonotkatska St., Kyiv 02094, Ukraine
  • Михаил В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

DOI:

https://doi.org/10.1007/5204

Keywords:

arylboronic acids, 4-aryl(hetaryl)pyrazolo[1, 5-a]pyrazines, 4-bromopyrazolo[1, palladium catalysis, Suzuki– Miyaura reaction.

Abstract

4-Bromopyrazolo[1,5-a]pyrazines react with aryl(hetaryl)boronic acids in the presence of catalytic amounts of Pd(dppf)Cl2·CH2Cl2 and an excess of Cs2CO3 in the MeCN–H2O, 9:1 solvent system with the formation of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines.

Author Biographies

Евгений В. Гринишин, National University ''Kyiv-Mohyla Academy'', 2 Hrygorija Skovorody St., Kyiv 04655, Ukraine Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

Аспирант в “Киево-Могилянской академии"

Анна Р. Мусийчук, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

Студент

Назар М. Цизорик, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

мнс в Институте органической химии НАН Украины

Андрей В. Больбут, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine Enamine Ltd., 67/45 Chervonotkatska St., Kyiv 02094, Ukraine

снс в Институте органической химии НАН Украины

Михаил В. Вовк, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02094, Ukraine

дхн проф. в Институте органической химии НАН Украины

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Published

2019-11-12

Issue

Vol. 55 No. 11 (2019)

Section

Original Papers