METHODS FOR THE SYNTHESIS OF IMMUNOSTIMULANT PLERIXAFOR

Authors

  • Нина К. Ратманова Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela St., Moscow 117997, Russia
  • Иван А. Андреев Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela St., Moscow 117997, Russia
  • Игорь В. Трушков Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela St., Moscow 117997, Russia N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

DOI:

https://doi.org/10.1007/5469

Keywords:

AMD3100, cyclam, Mozobil®, plerixafor, chemokine receptor CXCR4, oncoimmunology.

Abstract

This minireview discusses methods for the synthesis of the immunostimulant plerixafor (Mozobil®, AMD3100). The information presented covers the period from the publication of the first work devoted to the synthesis of plerixafor and the study of the electrochemical properties of its dinickel(II) and dicopper(II) complexes in 1987 to the present.

 

Author Biographies

Нина К. Ратманова, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela St., Moscow 117997, Russia

Лаборатория химического синтеза, с.н.с.

Иван А. Андреев, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela St., Moscow 117997, Russia

Лаборатория химического синтеза, с.н.с.

Игорь В. Трушков, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela St., Moscow 117997, Russia N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

зав. лаб. 33

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Published

2020-01-31

Issue

Vol. 56 No. 1 (2020)

Section

Review Articles