THE MAIN DIRECTIONS AND RECENT TRENDS IN THE SYNTHESIS AND USE OF ISOXAZOLES

Authors

  • Оксана Б. Бондаренко Lomonosov Moscow State University, 1, Build. 3 Leninskie Gory, Moscow 119991, Russia
  • Николай В. Зык Lomonosov Moscow State University, 1, Build. 3 Leninskie Gory, Moscow 119991, Russia

DOI:

https://doi.org/10.1007/5627

Keywords:

isoxazole, nitrile oxide, biological activity, condensation, cycloaddition, regioselectivity

Abstract

This review summarizes the main directions and recent trends in the synthesis of isoxazoles, and also provides examples of the use of isoxazoles as biologically active compounds in medicinal chemistry. When discussing the classical methods of isoxazole synthesis, the main emphasis is placed on the problem of selectivity of transformations. Bibliography includes 112 sources.

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Published

2020-07-10

Issue

Vol. 56 No. 6 (2020): Heterocyclic сompounds in medicinal chemistry

Section

Review Articles