SYNTHESIS AND EVALUATION OF THE CYTOTOXICITY OF INDENO[1,2-<i>c</i>]ISOQUINOLINE DERIVATIVES BEARING ESTER FUNCTIONAL GROUP AND 1,2,3-TRIAZOLE MOIETY

Authors

  • Hoai Thu Pham Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam
  • Giang Le-Nhat-Thuy Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam
  • Tuyet Thi Anh Dang Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam
  • Phuong Thi Hoang Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam
  • Tuan Anh Nguyen Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam
  • Thanh Ha Nguyen Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam
  • Tien Dung Nguyen Vietnam University of Traditional Medicine, Ha Dong, Hanoi 100000, Vietnam
  • Hanh Thuong Ngo Vietnam University of Traditional Medicine, Ha Dong, Hanoi 100000, Vietnam
  • Tuan Anh Le VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam
  • Tuyen Van Nguyen Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet St., Cau Giay, Hanoi 100000, Vietnam

DOI:

https://doi.org/10.1007/5693

Keywords:

indenoisoquinoline, 1, 2, 3-triazole, click chemistry, cytotoxicity, pharmacophore hybridization

Abstract

Synthesis of novel indeno[1,2-c]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC50) values in a range of 20–40 μM.

Author Biography

Tuan Anh Le, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam

hanhthuong1209@gmail.com Vietnam University of Traditional Medicine, Ha Dong, Ha Noi, Vietnam;

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Published

2020-10-14

Issue

Vol. 56 No. 9 (2020)

Section

Original Papers