BIOLOGICAL ACTIVITY AND SYNTHESIS OF 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID – BIOSYNTHETIC PRECURSOR OF MELANINS

Authors

  • Михаил А. Барабанов Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Георгий С. Мартьянов Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Александр В. Пестов Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620078, Russia

DOI:

https://doi.org/10.1007/6041

Keywords:

Melanin, indolecarboxylic acid, cancer, antiviral drugs, arbidol, immunodeficiency, coronavirus

Abstract

The microreview considers the biological activity and methods of obtaining natural melanin pigments and their biosynthetic precursor 5,6-dihydroxyindole-2-carboxylic acid. The key methods for the synthesis of 5,6-dihydroxyindole-2-carboxylic acid, published over the past 8 years (2012–
2020), are presented.

Author Biographies

Михаил А. Барабанов, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia

Лаборатория органических материалов, научный сотрудник

Георгий С. Мартьянов, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia

инженер-исследователь лаборатории органических материалов

Александр В. Пестов, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620078, Russia

И.о. зав. лаборатории органических материалов, старший научный сотрудник; доцент кафедры органической химии и высокомолекулярных соединений факультета ИЕНиМ УрФУ

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Published

2021-05-05

Issue

Vol. 57 No. 4 (2021): Heterocycles Against Viruses

Section

Heterocycles in Focus