NOVEL PURINE CONJUGATES WITH N-HETEROCYCLES: SYNTHESIS AND ANTI-INFLUENZA ACTIVITY

Authors

  • Виктор П. Краснов Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620062, Russia
  • Владимир В. Зарубаев Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Дмитрий А. Груздев Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620062, Russia
  • Ольга А. Воздвиженская Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Сергей А. Вакаров Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Вера В. Мусияк Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Евгений Н. Чулаков Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Александрина С. Волобуева Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Екатерина О. Синегубова Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Марина А. Ежикова Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Михаил И. Кодесс Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620062, Russia
  • Галина Л. Левит Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Валерий Н. Чарушин Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620062, Russia

DOI:

https://doi.org/10.1007/6054

Keywords:

ɷ-amino acids, 6-chloropurine, heterocyclic amines, antiviral activity, influenza A and B viruses.

Abstract

A number of novel amides were synthesized by coupling of 6-[(9H-purin-6-yl)amino]hexanoic acid to heterocyclic amines. The antiviral activity of the obtained compounds, as well as of purine conjugates in which 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine is linked to position 6 of purine through a fragment of ɷ-amino acids with varying lengths of polymethylene chains against influenza A and B viruses was studied in vitro. Purine derivatives have been shown to have moderate activity against influenza A (H1N1) virus. The antiinfluenza activity and cytotoxicity of conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine depend on the length of the linker fragment.

Author Biography

Виктор П. Краснов, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 Mira St., Yekaterinburg 620062, Russia

Заведующий лабораторией асимметрического синтеза

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Published

2021-05-05

Issue

Vol. 57 No. 4 (2021): Heterocycles Against Viruses

Section

Original Papers