3-CYANOAZOLO[5,1-<i>c</i>][1,2,4]TRIAZINES: SYNTHESIS AND ANTIVIRAL ACTIVITY

Authors

  • Ирина М. Сапожникова Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Евгений Н. Уломский Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Владимир Л. Русинов Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Олег Н. Чупахин Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Александр В. Степанов A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia, 15/17 Professora Popova St., Saint Petersburg 197376, Russia
  • Татьяна Н. Саватеева-Любимова A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia, 15/17 Professora Popova St., Saint Petersburg 197376, Russia
  • Константин В. Сивак A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia, 15/17 Professora Popova St., Saint Petersburg 197376, Russia

DOI:

https://doi.org/10.1007/6107

Keywords:

azoloazines, azolotriazines, nitriles, antiviral activity, Eastern equine encephalomyelitis, tick-borne encephalitis, Venezuelan equine encephalomyelitis.

Abstract

A series of azolo[5,1-c][1,2,4]triazines containing a cyano group were prepared as analogs of the drug Triazavirin (riamilovir). Sodium 3-cyano-7-methylsulfanyl-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-1-ide was tested for antiviral activity against the viruses of tickborne encephalitis, Venezuelan equine encephalomyelitis, and the Eastern equine encephalomyelitis using porcine embryonic kidney cell model and mouse model according to the emergency prophylaxis model and therapy model. The general toxicity of this compound was also characterized.

Author Biographies

Ирина М. Сапожникова, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia

Кафедра органической и биомолекулярной химии, младший научный сотрудник

Евгений Н. Уломский, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia

Кафедра органической и биомолекулярной химии, проф., д.х.н.

Владимир Л. Русинов, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia

Заведующий кафедрой органической и биомолекулярной химии, д.х.н., чл.-корр. РАН

Олег Н. Чупахин, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia

Кафедра органической и биомолекулярной химии, проф., академик РАН

Александр В. Степанов, A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia, 15/17 Professora Popova St., Saint Petersburg 197376, Russia

д.м.н., ведущий научный сотрудник

Татьяна Н. Саватеева-Любимова, A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia, 15/17 Professora Popova St., Saint Petersburg 197376, Russia

д.м.н., профессор, ведущий научный сотрудник

Константин В. Сивак, A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia, 15/17 Professora Popova St., Saint Petersburg 197376, Russia

к.б.н., заведующий отделом ДКИ

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Published

2021-05-05

Issue

Vol. 57 No. 4 (2021): Heterocycles Against Viruses

Section

Original Papers