PREPARATION OF AN ADDUCT OF LEVOGLUCOSENONE AND RESORCINOL AND ITS <i>in vitro</i> ANTIPLATELET AND ANTICOAGULANT ACTIVITY

Authors

  • Лилия Х. Файзуллина Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054, Russia
  • Юлия А. Халилова Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054, Russia
  • Фарид А. Валеев Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054, Russia
  • Валентин Н. Павлов Bashkir State Medical University, 3 Lenina St., Ufa 450008, Russia
  • Александр В. Самородов Bashkir State Medical University, 3 Lenina St., Ufa 450008, Russia

DOI:

https://doi.org/10.1007/6350

Keywords:

Michael adducts, levoglucosenone, mixed ketal, resorcinol, antiplatelet activity, anticoagulant activity.

Abstract

A procedure for the preparation of an adduct of levoglucosenone and resorcinol was developed involving ultrasonic irradiation in the presence of K2CO3 and 18-crown-6 ether in toluene. In vitro anticoagulant and antiplatelet activity of the adduct was studied.

 

Author Biography

Лилия Х. Файзуллина, Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054, Russia

к.х.н. по специальности 02.00.03 органическая химия, доцент, старший научный сотрудник лаборатории фармакофорных циклических систем

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Published

2021-09-22

Issue

Vol. 57 No. 9 (2021)

Section

Short Communications