CATALYTIC HYDROGENATION OF METHYL ESTERS OF SOME 1H-PYRAZOLINE-3-CARBOXYLIC ACIDS

Authors

  • В. А. Горпинченко Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • Д. В. Петров Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • C. C. Ложкин Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • Е. Г. Галкин Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • В. А. Докичев Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054

DOI:

https://doi.org/10.1007/6556

Keywords:

3-aminopyrrolidin-2-ones, methyl esters of 1H-pyrazoline-3-carboxylic acids, Raney nickel, catalytic hydrogenation, cyclocondensation

Abstract

Hydrogenation over Raney nickel of the methyl ester of 1H-pyrazoline-3-carboxylic acid and also of its 4-phenyl and 5-methoxycarbonyl-substituted analogs, leads respectively to 3-aminopyrrolidin-2-one, its 4-phenyl- and 5-methoxycarbonyl derivatives, predominantly to the trans isomer. Under the same conditions 1-amino-4-methoxycarbonylpyrrolidin-2-one was obtained from 3,4-di(methoxycarbonyl)-1H-pyrazoline, but 3,4,5-tri(methoxycarbonyl)-1H-pyrazoline did not react.

How to Cite
Gorpinchenko, V. A.;Petrov, D. V.; Lozhkin, S. S.; Galkin, E. G.;  Dokichev, V. A. Chem. Heterocycl. Compd. 2009, 45, 1202. [Khim. Geterotsikl. Soedin. 2009, 1500.]

For this article in the English edition see DOI 10.1007/s10593-010-0408-2

 

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Published

2022-02-09

Issue

No. 10 (2009)

Section

Original Papers