INVESTIGATIONS ON 5-(2-ARYL-2-OXOETHYLIDENE)-1,3-DIMETHYLBARBITURIC AND THIOBARBITURIC ACIDS: REACTIONS WITH THIOUREAS AND THIOACETAMIDE

Authors

  • Н. Н. Колос Chemical Faculty V. N. Karazin Kharkiv National University, Kharkiv 61077
  • Л. Л. Замигайло Chemical Faculty V. N. Karazin Kharkiv National University, Kharkiv 61077
  • В. И. Мусатов Institute for Single Crystals, National Academy of Sciences of Ukraine, Kharkiv 61001

DOI:

https://doi.org/10.1007/6618

Keywords:

5-(2-amino-4-arylthiazol-5-yl)-6-hydroxy-2-thioxo-2, 3-dihydropyrimidin-4(1H)-ones, 5-(2-amino-4-arylthiazol-5-yl)-1, 3-dimethylpyrimidine-2, 4-diones, 5-(2-aryl-2-oxoethylidene)-1, 3-dimethylbarbituric and 5-(2-aryl-2-oxoethylidene)thiobarbituric acids, thioacetamide, thioureas, one-pot synthesis, cyclocondensation

Abstract

Derivatives of 2-amino- and  2-methylthiazole  have  been synthesized by the  reaction of 5-(2-aryl-2-oxoethylidene)-1,3-dimethylbarbituric and thiobarbituric acids with thioureas and thioacetamide, and also by a one-pot synthesis involving thiourea (or thioacetamide), arylglyoxals, 1,3-dimethylbarbituric (or thiobarbituric) acids. The mechanisms of the studied reactions are discussed.

How to Cite
Kolos, N. N.; Zamigaylo, L. L.; Musatov, V. I.  Chem. Heterocycl. Compd. 2009, 45, 970. [Khim. Geterotsikl. Soedin. 2009, 1220.]

For this article in the English edition see DOI 10.1007/s10593-009-0365-9

 

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Published

2022-02-21

Issue

No. 8 (2009)

Section

Original Papers