4-HYDROXY-2-QUINOLONES. 152. 3-ACETYL-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE AND ITS BIOLOGICALLY ACTIVE DERIVATIVES
DOI:
https://doi.org/10.1007/6818Keywords:
3-acetyl-4-hydroxy-2-oxo-1, 2-dihydroquinolines, acetoacetic ester, hydrazides, hydrazones, 1-R-4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, antitubercular activity, X-ray structural analysisAbstract
A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related N,N'-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
How to Cite
Ukrainets, I. V.; Tkach, A. A.; Yang, L. Y. Chem. Heterocycl. Compd. 2009, 45, 169. [Khim. Geterotsikl. Soedin. 2009, 214.]
For this article in the English edition see DOI 10.1007/s10593-009-0246-2
