REGIOSELECTIVE SYNTHESIS OF FLUORINE-CONTAINING INDAZOLONES FROM 2-ACYLCYCLOHEXANE-1,3-DIONES

Authors

  • Т. С. Хлебникова Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk 220141
  • В. Г. Исакова Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk 220141
  • Ф. А. Лахвич Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk 220141
  • П. В. Курман The Republican Scientific and Engineering Center for Remote Sensing of Environment "EKOMIR", National Academy of Sciences of the Republic of Belarus, Minsk 220012

DOI:

https://doi.org/10.1007/7002

Keywords:

2-acylcyclohexane-1, 3-diones, fluorine-containing indazolones, regioselective synthesis

Abstract

New regioisomeric indazolones containing fluorine atoms in the aromatic ring have been synthesized in high yield by the interaction of 2-acylcyclohexane-1,3-diones, and of their enol methyl ethers, obtained by methylating the initial  β,β′-triketones with dimethyl sulfate in the presence of calcined potassium carbonate, with 4-fluorophenylhydrazine hydrochloride and with  pentafluorophenylhydrazine. The structures of the synthesized compounds were confirmed by data of IR and  1H,  13C, and  19F NMR spectra.

How to Cite
Khlebnicova, T. S.; Isakova, V. G.; Lakhvich, F. A.; Kurman, P. V.  Chem. Heterocycl. Compd. 2008, 44, 301. [Khim. Geterotsikl. Soedin. 2008, 393.]

For this article in the English edition see DOI 10.1007/s10593-008-0044-2


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Published

2022-08-22

Issue

No. 3 (2008)

Section

Original Papers