POLYCYCLIC SYSTEMS CONTAINING 1,2,4-OXADIAZOLE RING. 2. 4-(1,2,4-OXADIAZOL-5-YL)PYRROLIDIN-2-ONES: SYNTHESIS AND PREDICTION OF BIOLOGICAL ACTIVITY

Authors

  • Ю. В. Харченко V. N. Karazin National University, Kharkiv 61077
  • А. С. Детистов V. N. Karazin National University, Kharkiv 61077
  • В. Д. Орлов V. N. Karazin National University, Kharkiv 61077

DOI:

https://doi.org/10.1007/7073

Keywords:

1, 2, 4-oxadiazole, pyrrolidin-2-one, biological activity, one-pot synthesis

Abstract

A one-pot condensation of 5-oxopyrrolidine-3-carboxylic acids, carbonyldiimidazole, and benzamidoximes leads to the formation of the novel 4-(1,2,4-oxadiazol-5-yl)pyrrolidin-2-one bicyclic systems, the structures of which have been confirmed by IR and  1H NMR methods and by liquid chromato-mass spectrometry. The results of a PASS prediction of the biological activity of the synthesized compounds are presented.

How to Cite
Kharchenko, Yu. V.; Detistov, O. S.; Orlov, V. D. Chem. Heterocycl. Compd. 2008, 44, 600. [Khim. Geterotsikl. Soedin. 2008, 758.]

For this article in the English edition see DOI 10.1007/s10593-008-0080-y


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Published

2022-09-26

Issue

No. 5 (2008)

Section

Original Papers