RECENT PROGRESS IN THE DIRECT PHOSPHORYLATION OF PARENT HETEROCYCLES TO CONSTRUCT PHOSPHORYLATED HETEROCYCLES

Authors

  • Zhong Wen Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, 2025 Chengluo Ave., Chengdu 610016, P. R. China
  • Jun-Feng Deng Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, 2025 Chengluo Ave., Chengdu 610016, P. R. China
  • Long Chen Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, 2025 Chengluo Ave., Chengdu 610016, P. R. China Institute for Advanced Study, Chengdu University, 2025 Chengluo Ave., Chengdu 610016, P. R. China

DOI:

https://doi.org/10.1007/7254

Keywords:

C–P bond formation, cross-coupling reactions, phospha-Mannich reaction, phospha-Michael reaction, phosphorylation.

Abstract

This minireview summarizes the latest progress in the synthesis of phosphorylated heterocycles via the direct phosphorylation of parent heterocycles, covering four parts: 1) dehydrative cross couplings between P(O)–H compounds and alcohols; 2) cross-dehydrogenative couplings with P(O)–H compounds; 3) phospha-Michael or phospha-Mannich reaction, and 4) electrophilic phosphorylation of heterocycles.

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Published

2023-05-30

Issue

Vol. 59 No. 4/5 (2023)

Section

Review Articles