STEREOSELECTIVE SYNTHESIS OF TETRAHYDROPYRIMIDIN-2(1<i>H</i>)-ONES

Authors

  • Андрей В. Смолобочкин A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "''Kazan Scientific Center of the Russian Academy of Sciences'', 8 Akademika Arbuzova St., Kazan 420088
  • Альмир С. Газизов A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "''Kazan Scientific Center of the Russian Academy of Sciences'', 8 Akademika Arbuzova St., Kazan 420088

DOI:

https://doi.org/10.1007/7308

Keywords:

tetrahydropyrimidin-2(1H)-one, cyclization, stereoselectivity

Abstract

We provide a generalized overview of stereoselective synthetic strategies used for the preparation of tetrahydropyrimidin-2(1H)-one derivatives, illustrated by the most relevant examples published between years 2012 and 2022. The known methods can be divided into two main groups: intramolecular and intermolecular cyclization of unsaturated acyclic amides/ureas, as well as syntheses on the basis of cyclic precursors.

Authors: Andrey V. Smolobochkin*, Almir S. Gazizov

Author Biography

Андрей В. Смолобочкин, A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "''Kazan Scientific Center of the Russian Academy of Sciences'', 8 Akademika Arbuzova St., Kazan 420088

Старший научный сотрудник лаборатории элементорганического синтеза им. А.Н. Пудовика Института органической и физической химии им. А.Е. Арбузова ФИЦ Казанский научный центр РАН

Downloads

Published

2023-05-31

Issue

Vol. 59 No. 4/5 (2023)

Section

Heterocycles in Focus