SYNTHESIS AND PROPERTIES OF (6-METHYL-2-OXO-4-THIOXO-1,2,3,4-TETRAHYDRO-3-PYRIMIDINYL)ACETIC ACID METHYL ESTER

Authors

  • В. Якубкене Vilnius University, Vilnius LT-01513
  • Р. Паулаускайте Vilnius University, Vilnius LT-01513
  • П. Вайнилавичюс Vilnius University, Vilnius LT-01513

DOI:

https://doi.org/10.1007/7555

Keywords:

3-alkylated 4-amino-substituted 2-pyrimidinones, 3-substituted 2-oxo-4-thioxo-1, 2, 3, 4-tetrahydropyrimidines, pyrimido[6, 1-c][1, 4]triazine-3, 6-diones, alkylation, thionation

Abstract

On interacting of the methyl ester of (6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetic acid with the Lawesson's reagent the corresponding 4-thioxo derivative is synthesized. Its alkylation with methyl bromoacetate has been studied as has  its interaction with N-nucleophiles, amines, and hydrazines.

How to Cite
Jakubkiene, V.; Paulauskaite, R.; Vainilavicius, P.  Chem. Heterocycl. Compd. 2007, 43, 485. [Khim. Geterotsikl. Soedin. 2007, 590.]

For this article in the English edition see DOI 10.1007/s10593-007-0070-5


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Published

2023-03-24

Issue

No. 4 (2007)

Section

Original Papers