NEW OXAZOLE TO OXAZOLE RECYCLIZATION

Authors

  • Oleh V. Shablykin V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Akademika Kukharya St., Kyiv 02094, Ukraine
  • Danylo О. Merzhyievskyi V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Akademika Kukharya St., Kyiv 02094, Ukraine
  • Volodymyr S. Brovarets V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Akademika Kukharya St., Kyiv 02094, Ukraine
  • Svitlana V. Shishkina State Scientific Institution ''Institute for Single Crystals'', National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61001, Ukraine

DOI:

https://doi.org/10.1007/7623

Keywords:

5-aminooxazole-4-carbonitrile, 5-aminooxazole-4-carboxamide, oxazolo[5, 4-d]pyrimidin-7(6H)-one, trifluoroacetic acid, recyclization.

Abstract

(4-Cyanooxazol-5-ylamino)acetates and (4-cyanooxazol-5-ylamino)acetamides after treatment with trifluoroacetic acid undergo recyclization to the mixture of corresponding 5-aminooxazoles, 5-trifluoroacetylaminooxazoles, and oxazolopyrimidinones. The structures have been confirmed for certain products which have been isolated in pure form.

Author Biography

Volodymyr S. Brovarets, V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Akademika Kukharya St., Kyiv 02094, Ukraine

Chemistry of bioactive nitrogen-containing heterocyclic bases Dr. Chem. Sci., Prof.

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Published

2023-08-09

Issue

Vol. 59 No. 6/7 (2023): Ukrainian impact on heterocyclic chemistry after the three decades of independence

Section

Short Communications