A REGIOSELECTIVE SYNTHESIS OF 5-DIFLUOROMETHYL- AND 7-DIFLUOROMETHYL-SUBSTITUTED PYRAZOLO[1,5-<i>a</i>]PYRIMIDINES

Authors

  • Валерий С. Толкунов L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine 50 Kharkivs'ke shose St., Kyiv 02160, Ukraine
  • Андрей С. Толкунов L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine 50 Kharkivs'ke shose St., Kyiv 02160, Ukraine
  • Ольга В. Смирнова L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine 50 Kharkivs'ke shose St., Kyiv 02160, Ukraine
  • Сергей В. Толкунов L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine 50 Kharkivs'ke shose St., Kyiv 02160, Ukraine

DOI:

https://doi.org/10.1007/7661

Keywords:

5-aminopyrazoles, 1-cyclopropyl-4, 4-difluoro-1, 3-butanedione, 5-difluoromethylpyrazolo[1, 5-a]pyrimidines, 7-difluoromethylpyrazolo[1, 4, 4-difluoro-1-phenyl-1, trifluoroacetic acid, condensation.

Abstract

The cyclocondensation of 3,4-substituted 5-aminopyrazoles with unsymmetrical 1,3-dicarbonyl compounds containing the difluoromethyl group in acetic acid led to 7-difluoromethylpyrazolo[1,5-a]pyrimidines, whereas 5-difluoromethylpyrazolo[1,5-a]pyrimidine derivatives were predominantly formed in trifluoroacetic acid.

 

Author Biography

Валерий С. Толкунов, L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine 50 Kharkivs'ke shose St., Kyiv 02160, Ukraine

отдел химии гетероциклических соединений, канд.хим.наук, с.н.с.

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Published

2023-09-04

Issue

Vol. 59 No. 8 (2023)

Section

Original Papers