ACYLATION OF 2-AZAHETARYLACETONITRILES WITH (ACETYLTHIO)ACETYL AND α-(ACETYLTHIO)PROPIONYL CHLORIDES. PRODUCTION OF 5-AMINO-4-HETARYLTHIOPHEN-3(2H)-ONES

Authors

  • Ю. М. Воловенко Taras Shevchenko Kiev National University, Kiev 01043
  • Т. А. Воловненко Taras Shevchenko Kiev National University, Kiev 01043
  • А. В. Добрыднев Taras Shevchenko Kiev National University, Kiev 01043

DOI:

https://doi.org/10.1007/7809

Keywords:

2-azahetarylacetonitriles, 5-amino-4-hetarylthiophen-3(2H)-ones, (acetylthio)acetyl and α-(acetylthio)propionyl chlorides, acylation

Abstract

3-Cyano-3-hetaryl-2-oxopropyl-  and 3-cyano-3-hetaryl-1-methyl-2-oxopropyl ethanethioates were obtained  by  the acylation of 2-azahetarylacetonitriles with (acetylthio)acetyl and α-(acetylthio)propionyl chlorides  respectively. They are deacetylated by the action of  amines  and undergo cyclization with the formation of 5-amino-4-hetarylthiophen-2(2H)-ones.

How to Cite
Volovenko, Yu. M.; Volovnenko, T. A.; Dobrydnev, A. V.  Chem. Heterocycl. Compd. 2006, 42, 1137. [Khim. Geterotsikl. Soedin. 2006, 1314.]

For this article in the English edition see DOI 10.1007/s10593-006-0217-9


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Published

2023-05-18

Issue

No. 9 (2006)

Section

Original Papers