4-HYDROXY-2-QUINOLONES. 96. SYNTHESIS AND PROPERTIES OF 4-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkov 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkov 61002
  • О. В. Горохова National Pharmaceutical University, Kharkov 61002
  • C. В. Шишкина Institute of Scintillation Compounds, National Academy of Sciences of Ukraine, Kharkov 61001

DOI:

https://doi.org/10.1007/7954

Keywords:

4-methyl-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid, cyanoacetic ester, 4-chloroquinoline, amidation, hydrolysis, decarboxylation, X-ray structural analysis

Abstract

Alkaline hydrolysis of the ethyl ester of 4-(cyanoethoxycarbonylmethyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid is accompanied by decarboxylation with loss of two molecules of CO2  and leads to 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Gorokhova, O. V.; Shishkina, S. V.  Chem. Heterocycl. Compd. 2006, 42, 776. [Khim. Geterotsikl. Soedin. 2006, 887.]

For this article in the English edition see DOI 10.1007/s10593-006-0160-9


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Published

2023-08-15

Issue

No. 6 (2006)

Section

Original Papers