SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF ETHYNYLTHIAZOLES

Authors

  • A. Geronikaki Aristotles University of Thessaloniki, School of Pharmacy, Thessaloniki 54124
  • S. Vasilevsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk
  • D. Hadjipavlou-Litina Aristotles University of Thessaloniki, School of Pharmacy, Thessaloniki 54124
  • A. Lagunin Aristotles University of Thessaloniki, School of Pharmacy, Thessaloniki 54124
  • B. V. Poroikov V. N. Orekhnovich Institute of Biomedical Chemistry, RAMS, 119992 Moscow

DOI:

https://doi.org/10.1007/7990

Keywords:

ethynyl thiazoles, lipoxygenase (LOX), anti-inflammatory

Abstract

A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity.
Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean
lipoxygenase.

How to Cite
Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V.  Chem. Heterocycl. Compd. 2006, 42, 675. [Khim. Geterotsikl. Soedin. 2006, 769.]

For this article in the English edition, see DOI 10.1007/s10593-006-0145-8

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Published

2023-08-23

Issue

No. 5 (2006)

Section

Original Papers