4-HYDROXYQUINOL-2-ONES. 87. UNUSUAL SYNTHESIS OF 1-R-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACID PYRIDYLAMIDES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkov 61002
  • Л. В. Сидоренко National University of Pharmacy, Kharkov 61002
  • С. В. Слободзян Ohio Northern University, Ada 45810, Ohio
  • В. Б. Рыбаков M. V. Lomonosov State University, Moscow 119899
  • В. В. Чернышев M. V. Lomonosov State University, Moscow 119899

DOI:

https://doi.org/10.1007/8191

Keywords:

aminopyridine, 4-chloro-2-oxoquinoline-3-carboxylic acids, amidation, X-ray analysis

Abstract

4-Chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their esters react with aminopyridines in refluxing DMF to give the corresponding 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridylamides. Their structures were proved by 1H NMR and mass spectroscopy, counter synthesis, and by X-ray analysis. A possible mechanism is proposed for the indicated chemical reaction.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Slobodzyan, S. V.; Rybakov, V. B.; Chernyshev, V. V.  Chem. Heterocycl. Compd. 2005, 41, 1158. [Khim. Geterotsikl. Soedin. 2005, 1362.]

For this article in the English edition, see DOI 10.1007/s10593-005-0296-z

 

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Published

2023-10-20

Issue

No. 9 (2005)

Section

Original Papers