SYNTHESIS OF 5-[2-(PHENOXY)ETHYL] DERIVATIVES OF 6-METHYLURACIL, 6-METHYL-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE, AND 2-IMINO-6-METHYL-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE

Authors

  • М. С. Новиков Research Institute of Pharmacology, Volgograd State Medical University, Volgograd 400131
  • А. А. Озеров Research Institute of Pharmacology, Volgograd State Medical University, Volgograd 400131
  • О. Г. Сим Research Institute of Pharmacology, Volgograd State Medical University, Volgograd 400131

DOI:

https://doi.org/10.1007/8224

Keywords:

2-imino-6-methyl-5-[2-(phenoxy)ethyl]-2, 3-dihydro-1H-pyrimidin-4-ones, 6-methyl-2-thioxo-5-[2-(phenoxy)ethyl]-2, 6-methyl-5-[2-(phenoxy)ethyl]-2, synthesis

Abstract

A synthesis of novel derivatives of 6-methyluracil, 6-methyl-2-thioxo-, and 2-imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one containing a 2-(phenoxy)ethyl substituent at position 5 of the pyrimidine ring has been carried out. It was found that 5-[2-(phenoxy)ethyl] derivatives of 6-methyl-2-thioxo- and 2-imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one are obtained by the condensation of the corresponding ethyl 3-oxo-2-(2-phenoxyethyl)butanoates  with thiourea or guanidine. 6-Methyl-5-[2-(phenoxy)ethyl]uracils can be prepared by treating 6-methyl-5-[2-(phenoxy)ethyl]-2-thioxo-2,3-dihydro-1H-pyrimidin-4-ones with an excess of aqueous monochloroacetic acid solution.

How to Cite
Novikov, M. S.; Ozerov, A. A.; Sim, O. G.  Chem. Heterocycl. Compd. 2005, 41, 1036. [Khim. Geterotsikl. Soedin. 2005, 1213.]

For this article in the English edition, see DOI 10.1007/s10593-005-0275-4

 

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Published

2023-10-30

Issue

No. 8 (2005)

Section

Original Papers